REFERENCES

Genotique Nutrition Inc. is committed to maintaining the highest scientific standards, and we are continuously reviewing the literature to ensure we are up-to-date with the latest research. Below is our current list of references for the studies used to select the genetic markers in our personalized myGTQ reports. We performed an in-depth and extensive review of the literature in diet, exercise, health and nutrigenomics to select the strongest evidence to support our recommendations.

Our protocol to assess scientific strength includes evaluating the size of population studied, replication of the findings, the ethnicity of the cohort(s), and the results of any meta-analyses. The effect from the genetic polymorphisms we select must also be modifiable by diet or lifestyle to be included in our reports. We will be continuously updating this list and improving our reports and recommendations as the research continues to grow.


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Benyamin, B., M. A. Ferreira, G. Willemsen, S. Gordon, R. P. Middelberg, B. P. McEvoy, J. J. Hottenga, A. K. Henders, M. J. Campbell, L. Wallace, I. H. Frazer, A. C. Heath, E. J. de Geus, D. R. Nyholt, P. M. Visscher, B. W. Penninx, D. I. Boomsma, N. G. Martin, G. W. Montgomery, and J. B. Whitfield. 2009. ‘Common variants in TMPRSS6 are associated with iron status and erythrocyte volume’, Nat Genet, 41: 1173-5.

Benyamin, B., A. F. McRae, G. Zhu, S. Gordon, A. K. Henders, A. Palotie, L. Peltonen, N. G. Martin, G. W. Montgomery, J. B. Whitfield, and P. M. Visscher. 2009. ‘Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels’, Am J Hum Genet, 84: 60-5.

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Bufe, B., P. A. Breslin, C. Kuhn, D. R. Reed, C. D. Tharp, J. P. Slack, U. K. Kim, D. Drayna, and W. Meyerhof. 2005. ‘The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception’, Curr Biol, 15: 322-7.

Cahill, L. E., and A. El-Sohemy. 2009. ‘Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid’, J Nutrigenet Nutrigenomics, 2: 292-301.

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Chatzipapas, C., S. Boikos, G. I. Drosos, K. Kazakos, G. Tripsianis, A. Serbis, S. Stergiopoulos, C. Tilkeridis, D. A. Verettas, and C. A. Stratakis. 2009. ‘Polymorphisms of the vitamin D receptor gene and stress fractures’, Horm Metab Res, 41: 635-40.

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Chilton, F. H., R. Dutta, L. M. Reynolds, S. Sergeant, R. A. Mathias, and M. C. Seeds. 2017. ‘Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases’, Nutrients, 9.

Chiuve, S. E., E. L. Giovannucci, S. E. Hankinson, S. H. Zeisel, L. W. Dougherty, W. C. Willett, and E. B. Rimm. 2007. ‘The association between betaine and choline intakes and the plasma concentrations of homocysteine in women’, Am J Clin Nutr, 86: 1073-81.

Collins, M., M. Posthumus, and M. P. Schwellnus. 2010. ‘The COL1A1 gene and acute soft tissue ruptures’, Br J Sports Med, 44: 1063-4.

Contreras, A. V., N. Torres, and A. R. Tovar. 2013. ‘PPAR-alpha as a key nutritional and environmental sensor for metabolic adaptation’, Adv Nutr, 4: 439-52.

Corbin, K. D., and S. H. Zeisel. 2012. ‘Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression’, Curr Opin Gastroenterol, 28: 159-65.

Corella, D., D. K. Arnett, K. L. Tucker, E. K. Kabagambe, M. Tsai, L. D. Parnell, C. Q. Lai, Y. C. Lee, D. Warodomwichit, P. N. Hopkins, and J. M. Ordovas. 2011. ‘A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI’, J Nutr, 141: 2219-25.

Corella, D., G. Peloso, D. K. Arnett, S. Demissie, L. A. Cupples, K. Tucker, C. Q. Lai, L. D. Parnell, O. Coltell, Y. C. Lee, and J. M. Ordovas. 2009. ‘APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations’, Arch Intern Med, 169: 1897-906.

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Cornelis, M. C., L. Qi, P. Kraft, and F. B. Hu. 2009. ‘TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women’, Am J Clin Nutr, 89: 1256-62.

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da Costa, K. A., O. G. Kozyreva, J. Song, J. A. Galanko, L. M. Fischer, and S. H. Zeisel. 2006. ‘Common genetic polymorphisms affect the human requirement for the nutrient choline’, FASEB J, 20: 1336-44.

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de Luis, D. A., M. Gonzalez Sagrado, R. Aller, O. Izaola, and R. Conde. 2007. ‘Influence of the Trp64Arg polymorphism in the beta 3 adrenoreceptor gene on insulin resistance, adipocytokine response, and weight loss secondary to lifestyle modification in obese patients’, Eur J Intern Med, 18: 587-92.

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Dupuis, J., C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, A. U. Jackson, E. Wheeler, N. L. Glazer, N. Bouatia-Naji, A. L. Gloyn, C. M. Lindgren, R. Magi, A. P. Morris, J. Randall, T. Johnson, P. Elliott, D. Rybin, G. Thorleifsson, V. Steinthorsdottir, P. Henneman, H. Grallert, A. Dehghan, J. J. Hottenga, C. S. Franklin, P. Navarro, K. Song, A. Goel, J. R. Perry, J. M. Egan, T. Lajunen, N. Grarup, T. Sparso, A. Doney, B. F. Voight, H. M. Stringham, M. Li, S. Kanoni, P. Shrader, C. Cavalcanti-Proenca, M. Kumari, L. Qi, N. J. Timpson, C. Gieger, C. Zabena, G. Rocheleau, E. Ingelsson, P. An, J. O’Connell, J. Luan, A. Elliott, S. A. McCarroll, F. Payne, R. M. Roccasecca, F. Pattou, P. Sethupathy, K. Ardlie, Y. Ariyurek, B. Balkau, P. Barter, J. P. Beilby, Y. Ben-Shlomo, R. Benediktsson, A. J. Bennett, S. Bergmann, M. Bochud, E. Boerwinkle, A. Bonnefond, L. L. Bonnycastle, K. Borch-Johnsen, Y. Bottcher, E. Brunner, S. J. Bumpstead, G. Charpentier, Y. D. Chen, P. Chines, R. Clarke, L. J. Coin, M. N. Cooper, M. Cornelis, G. Crawford, L. Crisponi, I. N. Day, E. J. de Geus, J. Delplanque, C. Dina, M. R. Erdos, A. C. Fedson, A. Fischer-Rosinsky, N. G. Forouhi, C. S. Fox, R. Frants, M. G. Franzosi, P. Galan, M. O. Goodarzi, J. Graessler, C. J. Groves, S. Grundy, R. Gwilliam, U. Gyllensten, S. Hadjadj, G. Hallmans, N. Hammond, X. Han, A. L. Hartikainen, N. Hassanali, C. Hayward, S. C. Heath, S. Hercberg, C. Herder, A. A. Hicks, D. R. Hillman, A. D. Hingorani, A. Hofman, J. Hui, J. Hung, B. Isomaa, P. R. Johnson, T. Jorgensen, A. Jula, M. Kaakinen, J. Kaprio, Y. A. Kesaniemi, M. Kivimaki, B. Knight, S. Koskinen, P. Kovacs, K. O. Kyvik, G. M. Lathrop, D. A. Lawlor, O. Le Bacquer, C. Lecoeur, Y. Li, V. Lyssenko, R. Mahley, M. Mangino, A. K. Manning, M. T. Martinez-Larrad, J. B. McAteer, L. J. McCulloch, R. McPherson, C. Meisinger, D. Melzer, D. Meyre, B. D. Mitchell, M. A. Morken, S. Mukherjee, S. Naitza, N. Narisu, M. J. Neville, B. A. Oostra, M. Orru, R. Pakyz, C. N. Palmer, G. Paolisso, C. Pattaro, D. Pearson, J. F. Peden, N. L. Pedersen, M. Perola, A. F. Pfeiffer, I. Pichler, O. Polasek, D. Posthuma, S. C. Potter, A. Pouta, M. A. Province, B. M. Psaty, W. Rathmann, N. W. Rayner, K. Rice, S. Ripatti, F. Rivadeneira, M. Roden, O. Rolandsson, A. Sandbaek, M. Sandhu, S. Sanna, A. A. Sayer, P. Scheet, L. J. Scott, U. Seedorf, S. J. Sharp, B. Shields, G. Sigurethsson, E. J. Sijbrands, A. Silveira, L. Simpson, A. Singleton, N. L. Smith, U. Sovio, A. Swift, H. Syddall, A. C. Syvanen, T. Tanaka, B. Thorand, J. Tichet, A. Tonjes, T. Tuomi, A. G. Uitterlinden, K. W. van Dijk, M. van Hoek, D. Varma, S. Visvikis-Siest, V. Vitart, N. Vogelzangs, G. Waeber, P. J. Wagner, A. Walley, G. B. Walters, K. L. Ward, H. Watkins, M. N. Weedon, S. H. Wild, G. Willemsen, J. C. Witteman, J. W. Yarnell, E. Zeggini, D. Zelenika, B. Zethelius, G. Zhai, J. H. Zhao, M. C. Zillikens, Diagram Consortium, Giant Consortium, BPgen Consortium Global, I. B. Borecki, R. J. Loos, P. Meneton, P. K. Magnusson, D. M. Nathan, G. H. Williams, A. T. Hattersley, K. Silander, V. Salomaa, G. D. Smith, S. R. Bornstein, P. Schwarz, J. Spranger, F. Karpe, A. R. Shuldiner, C. Cooper, G. V. Dedoussis, M. Serrano-Rios, A. D. Morris, L. Lind, L. J. Palmer, F. B. Hu, P. W. Franks, S. Ebrahim, M. Marmot, W. H. Kao, J. S. Pankow, M. J. Sampson, J. Kuusisto, M. Laakso, T. Hansen, O. Pedersen, P. P. Pramstaller, H. E. Wichmann, T. Illig, I. Rudan, A. F. Wright, M. Stumvoll, H. Campbell, J. F. Wilson, Consortium Anders Hamsten on behalf of Procardis, Magic investigators, R. N. Bergman, T. A. Buchanan, F. S. Collins, K. L. Mohlke, J. Tuomilehto, T. T. Valle, D. Altshuler, J. I. Rotter, D. S. Siscovick, B. W. Penninx, D. I. Boomsma, P. Deloukas, T. D. Spector, T. M. Frayling, L. Ferrucci, A. Kong, U. Thorsteinsdottir, K. Stefansson, C. M. van Duijn, Y. S. Aulchenko, A. Cao, A. Scuteri, D. Schlessinger, M. Uda, A. Ruokonen, M. R. Jarvelin, D. M. Waterworth, P. Vollenweider, L. Peltonen, V. Mooser, G. R. Abecasis, N. J. Wareham, R. Sladek, P. Froguel, R. M. Watanabe, J. B. Meigs, L. Groop, M. Boehnke, M. I. McCarthy, J. C. Florez, and I. Barroso. 2010. ‘New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk’, Nat Genet, 42: 105-16.

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Eny, K. M., T. M. Wolever, B. Fontaine-Bisson, and A. El-Sohemy. 2008. ‘Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations’, Physiol Genomics, 33: 355-60.

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Eynon, N., M. Sagiv, Y. Meckel, J. A. Duarte, A. J. Alves, C. Yamin, M. Sagiv, E. Goldhammer, and J. Oliveira. 2009. ‘NRF2 intron 3 A/G polymorphism is associated with endurance athletes’ status’, J Appl Physiol (1985), 107: 76-9.

Fang, Y., J. B. van Meurs, P. Arp, J. P. van Leeuwen, A. Hofman, H. A. Pols, and A. G. Uitterlinden. 2009. ‘Vitamin D binding protein genotype and osteoporosis’, Calcif Tissue Int, 85: 85-93.

Ferrucci, L., J. R. Perry, A. Matteini, M. Perola, T. Tanaka, K. Silander, N. Rice, D. Melzer, A. Murray, C. Cluett, L. P. Fried, D. Albanes, A. M. Corsi, A. Cherubini, J. Guralnik, S. Bandinelli, A. Singleton, J. Virtamo, J. Walston, R. D. Semba, and T. M. Frayling. 2009. ‘Common variation in the beta-carotene 15,15′-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study’, Am J Hum Genet, 84: 123-33.

Fohr, I. P., R. Prinz-Langenohl, A. Bronstrup, A. M. Bohlmann, H. Nau, H. K. Berthold, and K. Pietrzik. 2002. ‘5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women’, Am J Clin Nutr, 75: 275-82.

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Fushan, A. A., C. T. Simons, J. P. Slack, and D. Drayna. 2010. ‘Association between common variation in genes encoding sweet taste signaling components and human sucrose perception’, Chem Senses, 35: 579-92.

Fushan, A. A., C. T. Simons, J. P. Slack, A. Manichaikul, and D. Drayna. 2009. ‘Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose’, Curr Biol, 19: 1288-93.

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